Integrate-and-fire Neurons Matched to Physiological F-i Curves Yield High Input Sensitivity and Wide Dynamic Range
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چکیده
Simple integrate-and-re neurons that accurately reproduce in vitro data from cortical regular spiking cells can display surprisingly sophisticated behavior. To reproduce in vitro f-I plots, voltage after spikes was reset to 5 mV below threshold , and simple spike rate adaptation was added. Small reset results in input sensitivity (high gain) on short time scales; adaptation leads to wide dynamic range over longer time scales. The model displays physiological ISI variability using either delta function or temporally realistic synaptic conductances. Cross correlation between pre-and post-synaptic spikes suggests that cortical neurons may be capable of transmitting information on the millisecond time scale.
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تاریخ انتشار 1997